There exists a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to decrease afferent soreness transmission and create analgesia. Consequently, medication like clonidine that goal alpha-2 receptors can influence the transmission of soreness. Relates to clonidine: oral tablet, oral tablet https://bookmarkize.com/story19801869/the-2-minute-rule-for-onolidine