There exists a launch of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to lower afferent soreness transmission and create analgesia. Therefore, medicines like clonidine that focus on alpha-2 receptors can influence the transmission of discomfort. Applies to clonidine: oral tablet, oral https://www.proleviate.com/post/the-new-pain-killer-conolidine