The use of animals in research has concerned the general public and thoughtful researchers for a long time. For improved animal welfare and increased research quality. researchers have moral obligations to include the 3Rs. The Three Rs are basic principles of humane experimental technique that were first set out by Russell and Burch in 1959. https://olivebookmarks.com/story19598849/microbial-biocontrol-strategies-for-ambrosia-beetles-and-their-associated-phytopathogenic-fungi