Ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will enhance the level or impact of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Acute ergot toxicity characterised by vasospasm and tissue ischemia has become affiliated with coadministration of ritonavir Because CYP3A4 inhibition elevates ergotamine and caffeine serum levels, the risk for va... https://cafergot-discontinued48371.tblogz.com/cafergot-discontinued-no-further-a-mystery-43430137